GPX4 and COVID-19: Intriguingly, the available data suggested that the selenium level is positively associated with clinical complications and outcomes,253,254 which supports selenium supplementation in COVID-19 patients.255 Selenium was reported to induce GPX4 expression to protect cells from ferroptosis in the model of stroke256 and further applied for COVID-19 (NCT04869579, NCT04798677, NCT04751669, NCT04323228).