DNASE1 and COVID-19: Dornase alfa is a FAD-approved recombinant human DNase I and showed significant effects of antiviral activity and disease relief of SARS-CoV-2 infection in vitro and in vivo.229 Currently, there are several clinical trials related dornase alfa for COVID-19 (NCT04432987, NCT04409925, NCT04409925, NCT04445285, NCT04402970, etc).