Importantly, SARS-CoV-2 infection initiates cytokine storm, in which inflammasome-dependent cell pyroptosis has been proven as the very important inducer, manifested by elevated levels of pro-inflammatory cytokines and chemokines,148 such as IL-6, IL-1β, TNFα, IL-8, IL-10, CXCL10, MCP1, which strongly correlated with the COVID-19 severity and mortality.79,149,150 In this context, these inflammatory mediators strongly promote cell migration and activation, further emphasizing the inflammatory environment and tissue damage. Here, IL6 is linked to COVID-19.