Importantly, SARS-CoV-2 infection initiates cytokine storm, in which inflammasome-dependent cell pyroptosis has been proven as the very important inducer, manifested by elevated levels of pro-inflammatory cytokines and chemokines,148 such as IL-6, IL-1β, TNFα, IL-8, IL-10, CXCL10, MCP1, which strongly correlated with the COVID-19 severity and mortality.79,149,150 In this context, these inflammatory mediators strongly promote cell migration and activation, further emphasizing the inflammatory environment and tissue damage. This evidence concerns the gene TNF and COVID-19.