In this regard, the histone deacetylase inhibitors (such as LBH589) with inhibitory effect on c-FLIP can be applied to COVID-19 patients.70 Many anti-inflammatory and antioxidative agents, such as phillyrin,71 dexamethasone,72 hydroxychloroquine,73 macrolide antibiotics,74 and N-acetylcysteine,75 have adverse effects on SARS-CoV-2 replication partially due to inhibition of the NF-κB pathway.76 It should be noticed that inhibiting NF-κB would contribute to significant side effects and adverse reactions for the reason that suppression of immune response. The gene discussed is NFKB1; the disease is COVID-19.