Cell pyroptosis causes numerous inflammatory cytokines release, among which IL-1β can in turn boost inflammasome activation in a positive feedback way.173,174 Thereby, that gives powerful support for direct inhibition of cytokines for COVID-19 treatment.175 Anakinra is an IL-1 receptor antagonist (IL-1RA) to block the binding of IL-1 with their receptor, which has obtained FDA approval for the treatment of rheumatoid arthritis and neonatal onset multisystem inflammatory disease. The gene discussed is IL1B; the disease is COVID-19.