Elevation of the ribosomal S6 protein kinase 1 (RPS6KB1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway was also associated with AMD, consistent with the AMD-like phenotype in mice with RPE mTOR overactivation54–56. The gene discussed is RPS6KB1; the disease is age-related macular degeneration.