APOB and age-related macular degeneration: This protein was found to be linked to two AMD-associated variants, rs2070895 and rs2043085 in or proximal to the LIPC gene (Supplementary Data 8 and Fig. 6e), as well as the APOB intron variant rs2678379 (Fig. 6e), which is a well-established regulator of plasma lipoprotein (HDL, LDL, and triglycerides) levels31.