The AMD associated variant rs10922109 in the CFH gene at 1q31.3, for example, was significantly associated with AMD in the AGES-RS (P = 2.6 × 10−16) (Supplementary Data 7) and influenced the levels of 40 serum proteins (Fig. 5 and Supplementary Data 7 and 8), including the AMD-associated proteins CFHR1, TST, DLL3, ST6GALNAC1, CFP, and NDUFS4 (Fig. 5, Table 1, and Supplementary Data 8). Here, CFHR1 is linked to age-related macular degeneration.