CFHR1 and age-related macular degeneration: The protective allele A for rs6677604 was significantly associated with reduced risk of late AMD in the AGES-RS cohort (β = −0.04, P = 3.0 × 10−7), and was also strongly linked with lower serum levels of CFHR1 (β = −1.33, P = 2.7 × 10−890; Supplementary Data 14).