As a matter of fact, KDM2A has been identified as a demethylase to demethylating H3K36me2, the covalent histone modification that involved in regulating a diverse range of biological processes including heterochromatin formation [39], X-chromosome inactivation and transcriptional regulation [40, 41], participating in regulating epithelial-mesenchymal identity, tumor differentiation, and metastasis [17]. This evidence concerns the gene MBD2 and neoplasm.