Quantification of maximum intensity projection confocal images revealed a 19.1% reduction in nuclear NUP62 (Fig. 1f) and a 279% enrichment of cytoplasmic NUP62 in C9-ALS/FTD iPSC neurons compared to controls (Fig. 1e-g, white arrows) (Control: 1.1 vs C9-ALS/FTD: 3.07 puncta/MAP2+ neuron). Here, NUP62 is linked to amyotrophic lateral sclerosis.