Given that Acsl4 showed the highest upregulation in LGG1 and the highest downregulation in GBM7, we selected patient-derived glioma cells PL1 and PG7 for subsequent experiments, which were respectively isolated from discarded LGG1 and GBM7 specimens (Fig. 1E, Supplementary Fig. 1B). The gene discussed is ACSL4; the disease is central nervous system cancer.