Mechanistically, it was found that overexpression of LINC01111 upregulated DUSP1 level through sponging miR-3924, leading to the impediment of SAPK phosphorylation as well as the deactivation of the SAPK/JNK signaling pathway in PC cells, thus suppressing PC aggressiveness [125]. The gene discussed is DUSP1; the disease is pachyonychia congenita.