Dual luciferase reporter (DLR) assay, RNA-immunoprecipitation (RIP) assay, as well as functional tests confirmed upregulated miR-23b-3p lowered abundance of KTN1-AS1 and HMGB2 in PC cells, ulteriorly suppressed cell propagation and aggressiveness, but enhanced apoptosis [98]. This evidence concerns the gene KTN1 and pachyonychia congenita.