APP KI and APP KI/14-3-3θ mice spent more time in the open arm in the elevated zero maze compared with the nTg mice, indicating decreased anxiety, but there was no difference between APP KI and APP KI/14-3-3θ mice (one-way ANOVA: F(2,31) = 11.17, p = 0.0002; Fig. 3D). This evidence concerns the gene APP and Anxiety.