YWHAQ and Alzheimer disease: Indeed, the functional 14-3-3 knock-out mice expressing the pan 14-3-3 inhibitor, difopein, show deficits mimicking several aspects of AD mouse models, including reduced spine density, reduced NMDAR subunits at the synapse, impaired long-term potentiation, and hippocampal-dependent learning and memory deficits (Qiao et al., 2014; Foote et al., 2015).