ADCY8 and diabetic kidney disease: All the biomarkers of renal injury in the urine were remarkably upregulated in DKD rats, including right kidney/body weight (Figure 4A), urine protein of 24 h (Figure 4B), urinary β-NAG/urinary creatinine (Figure 4C), serum urea nitrogen (Figure 4D), serum uric acid (Figure 4E), HbAc1 (Figure 4F).