In Cox regression analysis, we found that a history of HF (HR: 2.11, CI: 1.18–3.78, p = 0.012), CKD (HR: 1.95, CI: 1.18–3.2, p = 0.008) and the expression of circulating STAT3 (HR: 0.9, CI: 0.86–0.94, p = 0.001) were significantly associated with the occurrence of MALEs (Table 2). Here, STAT3 is linked to chronic kidney disease.