CTLA4 and melanoma: By applying the diverse models, they show that γδ T cells are more efficient than αβ T cells in migrating and infiltrating melanoma spheroids, as well as the other 3D models; however, the exposure to inflammatory and immunosuppressive signals delivered by the TME, readily induces CTLA‐4, PD‐1 and PD‐L1 upregulation, which leads to γδ T cell exhaustion, block of antitumor cytolytic activity and polarization into tumor‐promoting effectors, thus contributing to melanoma progression.2, 7