The results showed that CDKN1B overexpression rescued the proliferation (Supplementary Figure S7A), apoptosis (Supplementary Figure S7B) and cell cycle (Supplementary Figure S7C) of YTHDF2 overexpression ICC cells among HuCC‐T1 and HCCC‐9810 cells. The gene discussed is CDKN1B; the disease is intrahepatic cholangiocarcinoma.