Here, we identify Neuropilin-1, a host factor for infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Epstein-Barr virus (EBV), and human T cell lymphotropic virus type 1 (HTLV-1), as a direct cargo sorted by the endosomal SNX-BAR sorting complex promoting exit 1 (ESCPE-1). This evidence concerns the gene NRP1 and infection.