In the current study, we explored the changes in PD‐L1 expression and its mechanisms in cocultured CAR NK‐92 and CRPC cells, including a PCa cell line and primary cells from one patient with CRPC, and the effect of an anti‐PD‐L1 mAb on the antitumour activity of CAR NK‐92 cells in the absence or presence of CD8+ T cells. Here, CD274 is linked to posterior cortical atrophy.