Consistent with this, while the comparison between PID and ACSN Cadbiom models showed similar enriched GO terms, we observed differences in specific pathways such as the leptin signaling pathway, the IL27RA signaling pathway, the IL23R signaling pathway, the Neurotrophic factor mediated Trk signaling pathway and the Circadian rhythm pathway which are present in the PID model but absent in the ACSN model (see details in S1 Appendix). The gene discussed is IL23R; the disease is pelvic inflammatory disease.