PNPLA3 and steatosis: For instance, several single nucleotide polymorphisms (SNPs) such as patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane six superfamily member 2 (TM6SF2) and membrane bound O-acyltransferase domain-containing 7 (MBOAT7) appear to be associated with steatosis progression [21].