AGT occurs in humans as two polymorphic forms known as AGT-major (AGT-Ma) and AGT-minor (AGT-Mi); the latter occurs with an overall population frequency of 0.14 (SNP database: https://www.ncbi.nlm.nih.gov/snp/) but is around 0.46 among PH1 patients [16]. This evidence concerns the gene AGT and primary hyperoxaluria type 1.