EIF2AK3 and supranuclear palsy, progressive, 1: Moreover, it was shown that activation of PERK, a protein involved in unfolded protein response, the gene of which (EIF2AK3) was associated with PSP in a GWAS (Höglinger et al. 2011), rescued cultured human neurons in vitro and spinal cord neurons in mice in vivo from tau-induced toxicity in tauopathy models (Bruch et al. 2017).