Multivariate analyses using model 1 identified CTBG grade 3 as being associated with significantly increased hazard ratio for distant-organ metastasis only in cases with the luminal B/HER2-negative subtype of tumor (Table 5); multivariate analyses using model 2 clearly identified ProTBGS grade III as being associated with increased hazard ratios for tumor recurrence and distant-organ metastasis in patients with almost all intrinsic subtypes of tumor, except the basal-like subtype (Table 5). The gene discussed is ERBB2; the disease is neoplasm.