In UICC pTNM stage I cases, analysis using model 1 identified CTBG grade 3 and a Ki-67 labeling index of ≧20% as being significantly associated with tumor recurrence, and analysis using model 2 identified ProTBGS grade III and a Ki-67 labeling index of ≧20% as being significantly associated with tumor recurrence. The gene discussed is MKI67; the disease is neoplasm.