In cases with a Ki-67 labeling index ≤ 20%, analysis using model 1 failed to demonstrate any significant association of the CTBG with increased hazard ratios for tumor recurrence or distant-organ metastasis; on the other hand, presence of FF, invasive tumor size > 50 mm, and age ≦39 years were associated with significantly increased hazard ratios for tumor recurrence and distant-organ metastasis (Supplementary Table 3). Here, MKI67 is linked to neoplasm.