In cases with a Ki-67 labeling index of > 20%, CTBG grade 3 only significantly increased hazard ratio for tumor recurrence, while analysis using model 2 identified ProTBGS grade III as well as the presence of muscle invasion as being associated with increased hazard ratios for tumor recurrence, distant-organ metastasis, and tumor-related death (Supplementary Table 3). Here, MKI67 is linked to neoplasm.