MAPT and early-onset autosomal dominant Alzheimer disease: It was already described that highly purifiedtau protein can polymerize in vitro,9 yielding filaments similar to those found in the brainof Alzheimer’s disease patients,10 but not identical.11,12 Also, it is known that, in thepresence of heparin, filament polymerization accelerates for ON3Rtau isoform.3,4,13 Thus,we have tested the action of w-Tau peptide on tau protein aggregationin the presence or absence of heparin.