Sporadic venous malformations, the most common type of vascular malformations, are caused by gain‐of‐function mutations either in the endothelial tyrosine kinase receptor TEK/TIE2 or in the PI3K catalytic subunit alpha PIK3CA (Limaye et al, 2015; Castel et al, 2016; Castillo et al, 2016a); with TEK and PIK3CA mutations largely being mutually exclusive. The gene discussed is PIK3CA; the disease is vascular malformation.