Activation of the PI3K/AKT signalling pathway by genetic mutations in the endothelium is the primary etiological cause of most, if not all, low‐flow vascular malformations (Boscolo et al, 2015; Limaye et al, 2015; Luks et al, 2015; Castel et al, 2016; Castillo et al, 2016a). Here, AKT1 is linked to vascular malformation.