Interruption of the MTM1–BIN1 interaction, or overexpression of DNM2, may be sufficient to explain how MTM1 influences the triad, although the role of BIN1–MTM1 binding still requires further study, and the mechanism(s) by which DNM2 protein levels (but not RNA levels) are increased in XLMTM is unknown. Here, BIN1 is linked to X-linked myotubular myopathy.