Noteworthy, many pathways were also associated with autophagy pathways (e.g., autophagosome assembly, mTOR pathway, and PI3K‐Akt pathway) and AD‐related pathways (e.g., AGE‐RAGE pathway, histone deacetylation, and cholinergic synapse) both in the M‐TPAD and M‐IPAD models. This evidence concerns the gene MTOR and Alzheimer disease.