APOE and Alzheimer disease: This phenomenon implies that AD clusters can also be affected by ApoE genotypes, but simultaneously let us know that is not the only one reason for our clustering results, because our clusters from M‐TPAD and M‐IPAD do not show differences in ApoE genotypes between the clusters (Tables S5 and S6, Supporting Information) and seem to be affected by PI3K‐Akt pathways (mTOR independent; see “e” pathway in Figure 6f and Figure 7b) rather than mTOR‐dependent autophagic pathways.