There have been many changes in the condition of participants for 2 years (cognitive decline was observed in 63.5% of patients, PiB increase was observed in 77.9% of patients, FDG decrease was observed in 89.8% of patients, Hva decrease in 73.8% of patients, and clinical dementia rating changes in 26.8% of patients) (Figure S9, Supporting Information). Here, SMUG1 is linked to Mental deterioration.