Noteworthy, many pathways were also associated with autophagy pathways (e.g., autophagosome assembly, mTOR pathway, and PI3K‐Akt pathway) and AD‐related pathways (e.g., AGE‐RAGE pathway, histone deacetylation, and cholinergic synapse) both in the M‐TPAD and M‐IPAD models. The gene discussed is AGER; the disease is Alzheimer disease.