H2AX and breast carcinoma: AF induces single-strand DNA breaks and forms DNA–protein cross-links dependent on histone H2AX phosphorylation in BC cells.64,65 We previously showed that AF suppresses α6-integrin-Src-Akt signaling in breast cancer cells.12 TargetScanHuman8.0 also predicted ERRB2 as a miR125b-2–3p target.