To reduce selective bias, we compared the relationships between early albumin administration and 30-day mortality in patients with no albumin deficiency on the day1, the results showed that there was no statistical significance on minimum albumin levels on 1st day (2.8 vs. 2.5 g/dl, P = 0.072) between survivors and non-survivors in early albumin combination group (Supplementary Table 3). The gene discussed is ALB; the disease is hyperinsulinemic hypoglycemia, familial, 4.