An important role in the pathogenesis of GDM is played by insulin resistance and endothelial dysfunction, aggravated by unhealthy diet and sedentary lifestyle, which induce oxidative stress and the appearance of chronic inflammation and increasing inflammatory markers such as C-reactive protein, tumor necrosis factor-alpha (TNF-α), and interleukin (IL) 6. The gene discussed is TNF; the disease is gestational diabetes.