TLR3 and immune system disorder: From these analyses, we (a) identified candidate functional pathways that are responsible for innate immune disorders and respiratory diseases, such as Tuberculosis (hsa:05152), Primary Immunodeficiency (hsa:05340), and Influenza A (hsa:05164); (b) successfully replicated two Covid-19 associated SNPs (rs780744847 and rs541048548) mapped on genes TLR3 and ICAM3, respectively; and (c) suggested several candidate genes, including IL12RB1, TBK1, TLR3, and IFNGR2, which might be involved in SARS-CoV-2 cell entry, host immune responses, and Covid-19 disease severity.