In addition, multiple studies found that the pLoF variants in TLR7 gene enriched in severely affected male patients, and the deficiency of TLR7 would impair innate immunity and increase severity of COVID-19 (van der Made et al., 2020; Asano et al., 2021; Fallerini et al., 2021; Mantovani et al., 2021). Here, TLR7 is linked to COVID-19.