CXCL10 and pneumococcal pneumonia: However, in the last two decades, over-expression of IL-12, IFN-Υ, and IP-10 has emerged as a highly potent pro-inflammatory, neutrophil-mediated signaling axis in murine models of pneumococcal pneumonia (Yamamoto et al., 2004; Sun et al., 2007; Seyoum and Yano, 2011; Yamada et al., 2011; Gomez et al., 2015).