SNCA and Parkinson disease: α-S is coded by the SNCA gene, with severalpoint mutations in the gene known to cause familial forms of PD, includingA30P, A53T, and E46K mutations.8 A30P mutationretards9 the formation of both oligomersand fibrils and only this mutation affects the overall α-S structure.7 The E46K mutant increases membrane affinity10 and accelerates α-S aggregation and fibrilformation.11,12 The A53T mutant considerablyaccelerates α-S aggregation, and its fibril formation is fasterthan that of the wild-type (WT) α-S.13−15