A study reported increased expression levels of NLRP3 inflammasome-related molecules in PD patients; however, in another study, it was found that although there was a difference in the expression level of NLRP3 in the sera of PD patients compared to those of controls, the levels of IL-1β and IL-18 were not significantly different (Zhang et al., 2016; Fan et al., 2020). The gene discussed is IL18; the disease is Parkinson disease.