Research has found that there is no relationship between the polymorphisms of IL-1β−511 (rs16944) and IL-1β +3,953 (rs1143634) and the risk of MS; however, further studies revealed that early-onset MS had a higher association with heterozygosity of rs16944 than with homozygosity of rs16944 in IL-1β (Huang et al., 2013; Isik et al., 2013). The gene discussed is IL1B; the disease is myeloid sarcoma.