Studies have demonstrated that the abundance of Bacteroides decreased and that of Pseudomonas increased in the intestinal flora of MS patients, while the protein levels of NLRP3, ASC and cleaved caspase-1 increased in the CNS, and the mRNA levels of ASC and caspase-1 increased in the circulation (Pellegrini et al., 2020). Here, PYCARD is linked to myeloid sarcoma.