GDF15 and Insulin resistance: Yang et al. (2017) have demonstrated that GFRAL associates with the coreceptor RET to elicit intracellular signaling upon GDF15 binding and pointed toward an essential role for this GDF15/GDF15 axis in the reduction of food intake and regulation of body weight in obese mice. Furthermore, GDF15 has been linked to insulin resistance and circulating levels of GDF15 are increased in obese mice and humans as compared to non-obese controls (Kempf et al., 2012).