REN and type 2 diabetes mellitus: Moreover, the KEGG enrichment analysis of the differentially upregulated and downregulated genes for larval and adult stages is shown in Figures 5C,D, where upregulated genes were mainly enriched in cytoskeleton proteins, dilated cardiomyopathy, adrenergic signaling in cardiomyocytes, and glycolysis/gluconeogenesis, while downregulated genes were mainly enriched in the renin–angiotensin system, maturity onset diabetes of the young, mTOR signaling pathway, fatty acid degradation, cytochrome P450, and other pathways.