Markmiller et al. (2018) observed that the SG composition, dynamics, and localization are different in motor neurons with the Amyotrophic Lateral Sclerosis (ALS)-linked mutations in chromosome nine open reading frame 72 (C9orf72) or heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1). The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.