CDCA2 promoted the proliferation of HCC cells by promoting G1/S transition through the upregulation and activation of CCND1/CDK4/6 and CCNE1/CDK2, inhibited apoptosis by inactivating the p38 MAPK pathway and activating the JNK/c-Jun pathway in a p53/p21-dependent manner, and promoted the migration of Huh7 cells by activating the EMT pathway in vitro. Here, CCNE1 is linked to hepatocellular carcinoma.