TP53 and hepatocellular carcinoma: Furthermore, among the three HCC cell lines, Huh7 cells had the lowest apoptosis rate and were resistant to CDDP-induced cell death, as p53-dependent apoptosis modulates the cytotoxicity of anticancer agents, such as ionizing radiation, 5-fluorouracil, etoposide, and adriamycin (Lowe et al., 1993), and p53 defects promote CDDP resistance in HCC cells (Li et al., 2018).