The higher level of conserved residues across variants in gp36 (275 sequences) vs. gp41 (16,803 sequences) could be explained by the lower number of gp36 sequences in LANL due to the lower HIV-2 prevalence and worldwide infections (1–2 of 38 million HIV infections) explained by its lower transmissibility and virulence vs. HIV-1 (Azevedo-Pereira and Santos-Costa, 2016; Clinical Info and gov, 2019; Kapoor and Padival, 2021). This evidence concerns the gene PDPN and infection.