BRD4 and cardiac hypertrophy: In NRCMs stimulated by α1 receptor agonist phenylephrine or in mice induced by transverse aortic constriction (TAC), the expressions of all the BET family members remain unchanged (Anand et al., 2013) or with BRD4 upregulated only (Spiltoir et al., 2013), inconsistent with our observations that both BRD2 and BRD4 were upregulated in ISO-induced cardiac hypertrophy.