LOX and neoplasm: The metabolism of arachidonic acid through cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P-450 epoxygenase (EPOX) pathways leads to the generation of various biologically active eicosanoids, and inhibition of these pathways has generally been shown to inhibit tumor growth/progression (Cathcart et al., 2011).