A decrease in IFN-γ production in the peripheral blood and skin tissues of acute atopic dermatitis patients has been reported, and taking into consideration the fact that IFN-γ inhibits IgE production and Th2 lymphocyte proliferation (Renz et al., 1992; Leung et al., 2004; Simon D et al., 2004), the DHG water extracts are thought to suppress the skin inflammatory responses by inhibiting the Th2 cytokine production and regulating the IFN-γ expression. The gene discussed is IGHE; the disease is atopic eczema.