Nociceptive information from spinal cord and brainstem reaches CeA-CRF neurons through peptidergic afferent input from the parabrachial nucleus (Harrigan et al., 1994; Han et al., 2010) and in turn, the CeA is the major source of CRF-containing projection pathways to the extra-amygdalar targets promoting aversive and anxiety-like behaviors (Fendt et al., 1997; Marcilhac and Siaud, 1997; Beckerman et al., 2013; McCall et al., 2015; Pomrenze et al., 2015; Pomrenze et al., 2019a; Pomrenze et al., 2019b). The gene discussed is CRH; the disease is Anxiety.