CRH and major depressive disorder: The amygdala CRF system has been implicated in stress, fear, anxiety, and depression (Gafford and Ressler, 2016; Pomrenze et al., 2019a; Pliota et al., 2020) and is also recognized as an important player in pain-related plasticity and behavior (Fu and Neugebauer, 2008; Neugebauer, 2015; Ji and Neugebauer, 2019; Mazzitelli et al., 2021).