ERBB2 and neurodegenerative disease: Combined with the expression levels in the brain (Zhou et al., 2021) and the supporting literature evidence related to neurodegenerative diseases in vivo and in vitro, we screened out FBXL20, PPP1R1B, NEUROD2 (NDF2), and ERBB2 (HER2) for follow-up molecular biology experiments (Figure 6D).