TRPV1 and diabetes mellitus: It has been proven that TRPV1 activation may mediate the browning of white adipose tissue (WAT) via activating peroxisome proliferators–activated receptors γ (PPARγ), positive regulatory domain containing 16 (PRDM16), and the AMPK signaling pathway (Baskaran et al., 2016), which indicates that TRPV1 is a promising target against DM.