GCG and Other metabolic disease: In recent years, scientists have found TRPV1 plays an important role in metabolic diseases (Radu et al., 2013) and is associated with many signaling pathways such as pancreatic secretion, glucagon signaling, inflammatory mediator regulation of TRP channels, IR, and AMPK (Pabbidi et al., 2008; Sadeh et al., 2013).