CD47 and gastric neoplasm: Similar to the results presented here, the BGC-823 cell line showed upregulated mRNA expression of HIF-1 and cell-surface CD47 after bevacizumab treatment in vivo, suggesting that simultaneous blockade of the angiogenetic axis and CD47 axis significantly improved antitumour efficacy by facilitating macrophage infiltration and producing antitumour potency in experimental gastric tumour models.