TNFSF11 and osteoporosis: Several studies have shown that TFRD induces potential anti-osteoporosis activity by regulating targets in bone metabolic signaling pathways OPG/RANKL, and prevents and treats osteoporosis by inhibiting bone resorption or stimulating bone (Ibáñez, et al., 2019; Amin, et al., 2020; Ma, et al., 2020).