These oscillatory patterns were however disturbed in macrophages and neutrophils post-MI, which may be explained by alterations to the circadian clock network, in particular Sirt1 expression, which is shown to be downregulated in murine models of ischemia/reperfusion after a MI (Yang et al., 2013; Wang et al., 2018). The gene discussed is SIRT1; the disease is ischemia.