NFKB1 and neoplasm: In fact, the NF-κB pathway is often considered as a “double-edged sword”, its anti-inflammatory response varies with the condition, for example, immune cells in tumors can play a dual role under the regulation of the pathway, which can be anti-inflammatory and anti-tumor response, but also can promote the development of tumor immune escape response (Ben-Neriah and Karin, 2011; Taniguchi and Karin, 2018).