More surprisingly, it was found that inhibition of IKKβ in certain cells or tissues exacerbates inflammation spontaneously, making drug use less safe and certain.Charles et al. found that IKKβ inhibited tumor growth in Colla2-expressing fibroblasts in a CAC model, but this was strictly dependent on increased secretion of HGF, and their speculation is that IKKβ/NF-κB may have different functions in different subpopulations of fibroblasts (Pallangyo et al., 2015). This evidence concerns the gene NFKB1 and neoplasm.