CRP and diabetes mellitus: It has been observed that red wine consumption can decrease the level of inflammatory biomarkers related to cardiovascular disease (CVD) such as intercellular adhesion molecule-1 (ICAM-1), IL-6 (25, 26), interleukin 1α (IL-1α) (27) or C-reactive protein (CRP) (26, 28), besides decreasing plasma insulin levels and insulin resistance in patients with high cardiovascular risk and diabetes (29, 30).