LOX and neoplasm: Accordingly, alterations in the ECM of future sites of metastasis have been demonstrated in numerous cancer models.96 Decellularized matrix from the liver and lung of tumor-bearing mice significantly increases tumor cell adhesion compared to ECM from healthy mice.97 In the bones, upregulation of lysyl oxidase occurs in tandem with primary tumor formation, which increases bone stiffness and allows a more growth-permissive environment for cells that eventually intravasate.98,99