MAPT and Alzheimer disease: The authors speculated RHI associated with axonal injury could trigger different molecular pathways resulting in the accumulation of misfolded p-tau and other brain proteins, TDP-43, α-synuclein and β-amyloid explaining the high proportion of CTE cases with concomitant neurodegenerative disease (Motor Neuron Disease, Lewy Body Disease, Alzheimer's Disease) (20, 30).