These regions also appear to be more prone to alterations in epigenetic states and chromatin accessibility than the more constitutive heterochromatic domains of LADs, For example, in diseases caused by lamin mutations such as Hutchinson-Gilford Progeria Syndrome (HGPS), a premature aging laminopathy caused by mutations in the LMNA gene (Kohler et al., 2020; Shin and Worman, 2022). The gene discussed is LMNA; the disease is laminopathy.