HDAC3 and cancer: Binders, e.g., mimicking the lamin A-associated histone deacetylase HDAC3 (Demmerle et al., 2012), could also be introduced to simulate changes in chromatin states in LADs, such as those occurring in senescence (Chandra et al., 2012; Sadaie et al., 2013) or cancer (Dawson and Kouzarides, 2012).