To address the question whether Yy1 also plays a role in melanoma cell dissemination and metastasis formation, we analyzed lungs of non-injected Tyr::N-RasQ61KCdnk2a−/−Tyr::CreERT2R26R::Stop:EGFP Yy1lox/lox control mice and tamoxifen-injected Tyr::N-RasQ61KCdnk2a−/−Tyr::CreERT2R26R::Stop:EGFP Yy1lox/lox (Yy1 knockout) mice for metastatic lesions (Figure 5B). This evidence concerns the gene YY1 and melanoma.