MITF and melanoma: Likewise, interference with oxidative phosphorylation by administration of the drug oligomycin as well as disturbing protein biosynthesis by treating the cells with low doses of cycloheximide led to upregulation of NGFR and TGFB1 accompanied by downregulation of MITF (Figures 2B,C) similar to what has been observed in YY1-knockdown human melanoma cells (Figure 1H).