To investigate the role of YY1 in human melanoma cells, we performed siRNA-mediated YY1 knockdown experiments in three human melanoma cell lines with different mutational backgrounds, namely M010817 (NRASQ61K-mutated), Mel888 (BRAFV600E-mutated) and Skmel28 (BRAFV600E-mutated). Here, YY1 is linked to melanoma.