SLC39A8 was reported as one the major Mn2+ transporters of the plasma membrane of cells whose defect in SLC39A8-CDG patients leads to very low to undetectable Mn2+ concentrations in blood and causes intracellular Mn2+ deficiency (Choi et al., 2018); reviewed in Foulquier and Legrand (2020). Here, SLC39A8 is linked to congenital disorder of glycosylation.